Identification of molecular genetic contributants to canine cutaneous mast cell tumour metastasis by global gene expression analysis.
Cutaneous mast cell tumours are one of the most common canine cancers.Approximately 25% of the tumours metastasise.Activating c-kit mutations are Jodhpur Clips present in about 20% of tumours, but metastases occur in the absence of mutations.Tumour metastasis is associated with significantly diminished survival in spite of adjuvant chemotherapy.Ava